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KMID : 0369820070370060355
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 6 p.355 ~ p.358
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Formulation of Sustained Release Matrix Tablets Containing Ibudilast with Hydroxypropylmethylcellulose Phthalate and Ethylcellulose
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Oh Dong-Hoon
Yong Chul-Soon
Rhee Jong-Dal
Choi Han-Gon
Park Byung-Chul
Lee Jong-Suk
Ryu Dong-Sung
Jang Ki-Young
Im Jong-Seub
Sung Jung-Hoon
Han Myo-Jung
Kwon Tae-Hyub
Yang Ho-Joon
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Abstract
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To develop a sustained-release tablet which had the similar dissolution to commercial ibudilast-loaded sustained-release capsule, the tablets were prepared using hydroxypropylmethylcellulose phthalate (HPMCP), ethylcellulose (EC) and hydroxypropylcellulose (HPC), and dissolution test were carried out with paddle method in KP. The tablet prepared only with HPMCP and EC showed sno similar dissolution pattern to the commercial product. As the ratio of HPMCP/HPC in tablet decreased, the dissolution rate of drug decreased in pH 1.2 but increased in pH 6.8. Furthermore, an ibudilast-loaded sustained-release tablet composed of [ibudilast/EC/HPMCP/HPC (10/10/170/10 mg/tab)] gave similar dissolution to commercial product in pH 1.2 for 3 h and in pH 6.8 for 10 h. Thus, it could be a potential candidate for the substitute of commercial capsule.
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KEYWORD
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Ibudilast, Sustained release tablet, Dissolution, HPMCP, EC, HPC
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